| Autor: |
Santovito D, Weber C; Christian Weber, MD, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 440054530, Fax: +49 89 440054532, E-mail: chweber@med.lmu.de. |
| Jazyk: |
angličtina |
| Zdroj: |
Thrombosis and haemostasis [Thromb Haemost] 2017 Jan 26; Vol. 117 (2), pp. 231-237. Date of Electronic Publication: 2016 Dec 15. |
| DOI: |
10.1160/TH16-10-0770 |
| Abstrakt: |
Compelling experimental results have substantiated the immune-driven inflammatory nature of atherosclerosis. Most of the scientific advances over the past decades have been achieved by relying on transgenic animal models that have been employed with increasing levels of sophistication. However, recent failures in translating various anti-inflammatory therapeutic strategies for use in humans might raise some skepticism with regards to an inflammatory causality underlying human atherosclerosis. By applying a dialectical approach, this Perspective aims to challenge and deduce the nature of atherosclerosis by reviewing results exclusively derived from human studies and recent clinical trials, as "things may not always be, what they appear". |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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