Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress.

Autor:	Surya VN; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA., Michalaki E; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA., Huang EY; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA., Fuller GG; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA., Dunn AR; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA alex.dunn@stanford.edu.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
Jazyk:	angličtina
Zdroj:	Journal of the Royal Society, Interface [J R Soc Interface] 2016 Dec; Vol. 13 (125).
DOI:	10.1098/rsif.2016.0823
Abstrakt:	The endothelial cells that line blood and lymphatic vessels undergo complex, collective migration and rearrangement processes during embryonic development, and are known to be exquisitely responsive to fluid flow. At present, the molecular mechanisms by which endothelial cells sense fluid flow remain incompletely understood. Here, we report that both the G-protein-coupled receptor sphingosine 1-phosphate receptor 1 (S1PR1) and its ligand sphingosine 1-phosphate (S1P) are required for collective upstream migration of human lymphatic microvascular endothelial cells in an in vitro setting. These findings are consistent with a model in which signalling via S1P and S1PR1 are integral components in the response of lymphatic endothelial cells to the stimulus provided by fluid flow. (© 2016 The Author(s).)
Databáze:	MEDLINE
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