Shock-like haemodynamic responses induced in the primary visual cortex by moving visual stimuli.

Autor:	Lacy TC; School of Physics, University of Sydney, New South Wales, Australia tlacy@physics.usyd.edu.au.; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia., Aquino KM; School of Physics, University of Sydney, New South Wales, Australia.; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia.; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Robinson PA; School of Physics, University of Sydney, New South Wales, Australia.; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia., Schira MM; School of Psychology, University of Wollongong, Wollongong, New South Wales 2522, Australia.; Neuroscience Research Australia, Royal Hospital for Women, Randwick, New South Wales 2031, Australia.
Jazyk:	angličtina
Zdroj:	Journal of the Royal Society, Interface [J R Soc Interface] 2016 Dec; Vol. 13 (125).
DOI:	10.1098/rsif.2016.0576
Abstrakt:	It is shown that recently discovered haemodynamic waves can form shock-like fronts when driven by stimuli that excite the cortex in a patch that moves faster than the haemodynamic wave velocity. If stimuli are chosen in order to induce shock-like behaviour, the resulting blood oxygen level-dependent (BOLD) response is enhanced, thereby improving the signal to noise ratio of measurements made with functional magnetic resonance imaging. A spatio-temporal haemodynamic model is extended to calculate the BOLD response and determine the main properties of waves induced by moving stimuli. From this, the optimal conditions for stimulating shock-like responses are determined, and ways of inducing these responses in experiments are demonstrated in a pilot study. (© 2016 The Author(s).)
Databáze:	MEDLINE
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