Clinical Cancer Genetics Disparities among Latinos.

Autor: Cruz-Correa M; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA. marcia.cruz1@upr.edu.; Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR, USA. marcia.cruz1@upr.edu., Pérez-Mayoral J; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA.; Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR, USA., Dutil J; Ponce Research Institute, Ponce Health Sciences University, Ponce, PR, USA., Echenique M; Cancer Center, Auxilio Mutuo Hospital, San Juan, PR, USA., Mosquera R; Puerto Rico Gastroenterology Association, San Juan, PR, USA., Rivera-Román K; Department of Pediatrics, University of Puerto Rico School of Medicine, San Juan, PR, USA., Umpierre S; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA., Rodriguez-Quilichini S; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA., Gonzalez-Pons M; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA.; Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR, USA., Olivera MI; Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA.; Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR, USA., Pardo S; Department of Pathology, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Jazyk: angličtina
Zdroj: Journal of genetic counseling [J Genet Couns] 2017 Jun; Vol. 26 (3), pp. 379-386. Date of Electronic Publication: 2016 Dec 12.
DOI: 10.1007/s10897-016-0051-x
Abstrakt: The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.
Databáze: MEDLINE
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