Living donor risk model for predicting kidney allograft and patient survival in an emerging economy.

Autor: Zafar MN; Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan., Wong G; Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia., Aziz T; Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan., Abbas K; Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan., Adibul Hasan Rizvi S; Department of Urology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Jazyk: angličtina
Zdroj: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2018 Mar; Vol. 23 (3), pp. 279-286.
DOI: 10.1111/nep.12983
Abstrakt: Aim: Living donor kidney is the main source of donor organs in low to middle income countries. We aimed to develop a living donor risk model that predicts graft and patient survival in an emerging economy.
Methods: We used data from the Sindh Institute of Urology and Transplantation (SIUT) database (n = 2283 recipients and n = 2283 living kidney donors, transplanted between 1993 and 2009) and conducted Cox proportional hazard analyses to develop a composite score that predicts graft and patient survivals.
Results: Donor factors age, creatinine clearance, nephron dose (estimated by donor/recipient body weight ratio) and human leukocyte antigen (HLA) match were included in the living donor risk model. The adjusted hazard ratios (HRs) for graft failures among those who received a kidney with living donor scores (reference to donor score of zero) of 1, 2, 3 and 4 were 1.14 (95%CI: 0.94-1.39), 1.24 (95%CI:1.03-1.49), 1.25 (95%CI:1.03-1.51) and 1.36 (95%CI:1.08-1.72) (P-value for trend =0.05). Similar findings were observed for patient survival.
Conclusions: Similar to findings in high income countries, our study suggests that donor characteristics such as age, nephron dose, creatinine clearance and HLA match are important factors that determine the long-term patient and graft survival in low income countries. However, other crucial but undefined factors may play a role in determining the overall risk of graft failure and mortality in living kidney donor transplant recipients.
(© 2016 Asian Pacific Society of Nephrology.)
Databáze: MEDLINE
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