Topical 1% 5-fluoruracil as a sole treatment of corneoconjunctival ocular surface squamous neoplasia: long-term study.

Autor:	Parrozzani R; G.B. Bietti Foundation, IRCCS, Ocular Oncology and Toxicology Research Unit, Roma, Italy., Frizziero L; Department of Ophthalmology, University of Padova, Padova, Italy., Trainiti S; Department of Ophthalmology, University of Padova, Padova, Italy., Testi I; Department of Ophthalmology, University of Padova, Padova, Italy., Miglionico G; Department of Ophthalmology, University of Padova, Padova, Italy., Pilotto E; Department of Ophthalmology, University of Padova, Padova, Italy., Blandamura S; Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padova, Padova, Italy., Fassina A; Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padova, Padova, Italy., Midena E; G.B. Bietti Foundation, IRCCS, Ocular Oncology and Toxicology Research Unit, Roma, Italy.; Department of Ophthalmology, University of Padova, Padova, Italy.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2017 Aug; Vol. 101 (8), pp. 1094-1099. Date of Electronic Publication: 2016 Dec 09.
DOI:	10.1136/bjophthalmol-2016-309219
Abstrakt:	Aims: To report long-term clinical outcome of topical 1% 5-fluoruracil (5-FU) as a sole treatment of ocular surface squamous neoplasia (OSSN). Methods: 41 patients affected by OSSN were included. Each patient underwent full ophthalmological examination at baseline, with cytological or histological confirmation. Patients were treated by topical chemotherapy with 1% 5-FU four times a day for 4 weeks. One course was defined as 4 weeks of topical chemotherapy. Adjunctive courses were administered after 1 month of chemotherapy-free interval. Results: Mean follow-up was 105±32 months (range 60-171 months). Complete tumour regression was achieved in 34 cases (83%) after a mean of 1.5 courses (range, 1-3 courses). Univariate analysis revealed that complete response was significantly related to tumour thickness <1.5 mm (p=0.005), lack of fornix or tarsal involvement (p=0.015 and p=0.009, respectively) and the absence of multifocality (p=0.002). Histopathological diagnosis (intraepithelial neoplasia vs squamous cell carcinoma, p=0.019) and American Joint Committee on Cancer (AJCC) classification (T1 vs T2 or T3) (p=0.028) were also related to incomplete tumour response. In a multivariate analysis, just tumour thickness >1.5 mm (p=0.045) and multifocality (p=0.023) were correlated with incomplete tumour response. Transient and reversible low-to-mild local side effects were documented in 19 (48%) eyes. Conclusion: Topical 5-FU, as a sole therapy, is a long-term safe and effective treatment for patients affected by preinvasive OSSN and for a limited proportion (50%) of invasive OSSN. Competing Interests: Competing interests: None. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
Databáze:	MEDLINE
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