Serotypes, antimicrobial resistance and genotypes of Streptococcus pneumoniae associated with infections in cancer patients in Brazil.

Autor: Cardoso NT; Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: nay.torresbio@gmail.com., Santos BA; Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: barbara.araujo1989@bol.com.br., Barbosa AV; Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: andre_ctbp@yahoo.com.br., Superti SV; Instituto Nacional de Câncer, Praça Cruz Vermelha, 23, Centro, Rio de Janeiro, RJ, Brazil. 20230-130. Electronic address: nanasuperti@gmail.com., Teixeira LM; Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Departamento de Microbiologia Médica, Avenida Carlos Chagas Filho, 373 - bloco I, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil, 21941-902. Electronic address: lmt2@micro.ufrj.br., Neves FP; Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: fpgneves@vm.uff.br.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2017 Mar; Vol. 87 (3), pp. 281-285. Date of Electronic Publication: 2016 Nov 28.
DOI: 10.1016/j.diagmicrobio.2016.11.017
Abstrakt: We sought to characterize pneumococcal isolates associated with bacteremia, pneumonia and meningitis in cancer patients and to estimate the coverage of the available pneumococcal vaccines. Fifty isolates recovered from 49 patients attending a cancer reference center over a 1-year period were analyzed. The prevalent serotypes were: 23F (12%), 6A (8%), 3, 4, 20, and 23A (6% each). All isolates were susceptible to chloramphenicol, levofloxacin, rifampicin, and vancomycin. Resistance or reduced susceptibility to penicillin made up 14%, and one isolate was also intermediately resistant to ceftriaxone. The three (6%) erythromycin-resistant isolates presented the M or cMLS B phenotypes and harbored the mef(A/E) gene exclusively or along with the erm(B) gene. Twenty-two (44%) isolates were closely related to 11 international clones, being strongly associated with penicillin non-susceptibility. Combined immunization with the 13-valent conjugate and the 23-valent polysaccharide vaccines might contribute to reduce (76%) the burden of the pneumococcal infections in the population investigated.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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