| Autor: |
Shadrina AS; 1 Institute of Chemical Biology and Fundamental Medicine, Russia.; 2 Novosibirsk State University, Russia., Smetanina MA; 1 Institute of Chemical Biology and Fundamental Medicine, Russia., Sokolova EA; 1 Institute of Chemical Biology and Fundamental Medicine, Russia.; 2 Novosibirsk State University, Russia., Shamovskaya DV; 1 Institute of Chemical Biology and Fundamental Medicine, Russia., Sevost'ianova KS; 1 Institute of Chemical Biology and Fundamental Medicine, Russia., Shevela AI; 1 Institute of Chemical Biology and Fundamental Medicine, Russia., Soldatsky EY; 3 Pirogov Russian National Research Medical University, Russia., Seliverstov EI; 3 Pirogov Russian National Research Medical University, Russia., Demekhova MY; 4 Private Surgery Center 'Medalp', Russia., Shonov OA; 4 Private Surgery Center 'Medalp', Russia., Ilyukhin EA; 4 Private Surgery Center 'Medalp', Russia., Voronina EN; 1 Institute of Chemical Biology and Fundamental Medicine, Russia.; 2 Novosibirsk State University, Russia., Pikalov IV; 5 Novosibirsk State Medical University, Russia., Zolotukhin IA; 3 Pirogov Russian National Research Medical University, Russia., Kirienko AI; 3 Pirogov Russian National Research Medical University, Russia., Filipenko ML; 1 Institute of Chemical Biology and Fundamental Medicine, Russia.; 2 Novosibirsk State University, Russia. |
| Abstrakt: |
Objective To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio = 0.73, 95% confidence interval = 0.59-0.91, P = 0.004). Conclusions Our results provide evidence that polymorphism rs2010963 located in the 5' untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein. |
