Usefulness of admission red blood cell distribution width as a predictor of severity of acute pulmonary embolism.

Autor: Akgedik R; Department of Chest Diseases, Faculty of Medicine, Ordu University, Ordu, Turkey., Karamanli H; Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research State Hospital, Ankara, Turkey., Kurt AB; Department of Radiology, Faculty of Medicine, Ordu University, Ordu, Turkey., Günaydın ZY; Department of Cardiology, Faculty of Medicine, Ordu University, Ordu, Turkey.
Jazyk: angličtina
Zdroj: The clinical respiratory journal [Clin Respir J] 2018 Feb; Vol. 12 (2), pp. 786-794. Date of Electronic Publication: 2017 Jan 08.
DOI: 10.1111/crj.12595
Abstrakt: Background: Previous researches have represented a considerable relation between acute pulmonary embolism (PE) and red blood cell distribution width (RDW). To the authors' knowledge no research has been informed in subjects with PE severity. Pulmonary arterial obstruction index (PAOI) is associated with the severity of acute PE.
Objectives: In our investigation, we purposed to assess the relation between PAOI and RDW and the benefit of these factors in the detection of PE severity.
Methods: We retrospectively investigated the demographic information, probability of clinical scores, laboratory parameters, serum D-dimer levels, and echocardiographic findings of systolic pulmonary artery pressure (PAP) in Acute PE individuals who were diagnosed by computed tomography of pulmonary arterial angiography. Right ventricular dysfunction (RVD) on CT was assessed by calculating the right ventricular/left ventricular (RV/LV) diameter ratios on transverse (RV/LVtrans).
Results: The information of 131 patients with acute PE and 51 (64.6%) female and 28 (35.4%) male healthy control were evaluated. Acute PE group's RDW values were higher than control subjects (P < .0001). RDW (%) level was remarkable higher in patients with massive PE than in patients with nonmassive PE. There were statistically considerable differences in terms of PAOI and systolic pulmonary arterial pressure (sPAP) between nonmassive and massive PE patients (P < .0001 for all).
Conclusions: PAOI was correlated with PE severity, D-dimer level, sPAP and clinical probability scores. PAOI was correlated with RDW levels. RDW levels, an inexpensive and easily measurable laboratory factor, were considerable associated with the severity and presence of PE.
(© 2016 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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