N-Terminal Pro-B-Type Natriuretic Peptide and Subclinical Brain Damage in the General Population.

Autor: Zonneveld HI; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Ikram MA; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Hofman A; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Niessen WJ; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., van der Lugt A; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Krestin GP; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Franco OH; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.)., Vernooij MW; From the Departments of Epidemiology (H.I.Z., M.A.I., A.H., O.H.F., M.W.V.), Radiology and Nuclear Medicine (H.I.Z., M.A.I., W.J.N., A.v.d.L., G.P.K., M.W.V.), Neurology (M.A.I.), and Medical Informatics (W.J.N.), Erasmus MC, University Medical Center Rotterdam, Room Na28-18, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass (A.H.); and Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands (W.J.N.).
Jazyk: angličtina
Zdroj: Radiology [Radiology] 2017 Apr; Vol. 283 (1), pp. 205-214. Date of Electronic Publication: 2016 Dec 07.
DOI: 10.1148/radiol.2016160548
Abstrakt: Purpose To investigate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is a marker of heart disease, and markers of subclinical brain damage on magnetic resonance (MR) images in community-dwelling middle-aged and elderly subjects without dementia and without a clinical diagnosis of heart disease. Materials and Methods This prospective population-based cohort study was approved by a medical ethics committee overseen by the national government, and all participants gave written informed consent. Serum levels of NT-proBNP were measured in 2397 participants without dementia or stroke (mean age, 56.6 years; age range, 45.7-87.3 years) and without clinical diagnosis of heart disease who were drawn from the population-based Rotterdam Study. All participants were examined with a 1.5-T MR imager. Multivariable linear and logistic regression analyses were used to investigate the association between NT-proBNP level and MR imaging markers of subclinical brain damage, including volumetric, focal, and microstructural markers. Results A higher NT-proBNP level was associated with smaller total brain volume (mean difference in z score per standard deviation increase in NT-proBNP level, -0.021; 95% confidence interval [CI]: -0.034, -0.007; P = .003) and was predominantly driven by gray matter volume (mean difference in z score per standard deviation increase in NT-proBNP level, -0.037; 95% CI: -0.057, -0.017; P < .001). Higher NT-proBNP level was associated with larger white matter lesion volume (mean difference in z score per standard deviation increase in NT-proBNP level, 0.090; 95% CI: 0.051, 0.129; P < .001), with lower fractional anisotropy (mean difference in z score per standard deviation increase in NT-proBNP level, -0.048; 95% CI: -0.088, -0.008; P = .019) and higher mean diffusivity (mean difference in z score per standard deviation increase in NT-proBNP level, 0.054; 95% CI: 0.018, 0.091; P = .004) of normal-appearing white matter. Conclusion In community-dwelling persons, higher serum NT-proBNP levels are associated with volumetric and microstructural MR imaging markers of subclinical brain damage. © RSNA, 2016 Online supplemental material is available for this article.
Databáze: MEDLINE