Gas6 as a putative noninvasive biomarker of hepatic fibrosis.

Autor:	Bellan M; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Pogliani G; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Marconi C; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Minisini R; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Franzosi L; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Alciato F; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy., Magri A; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy., Avanzi GC; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Emergency Medicine Department, 'AOU Maggiore della Carità', Corso Mazzini 18, Novara, Italy., Pirisi M; Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy.; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy.; IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, via Solaroli 17, Novara, Italy., Sainaghi PP; Division of Internal Medicine, 'AOU Maggiore della Carità', Corso Mazzini 18, 28100 Novara, Italy.; IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, via Solaroli 17, Novara, Italy.
Jazyk:	angličtina
Zdroj:	Biomarkers in medicine [Biomark Med] 2016 Dec; Vol. 10 (12), pp. 1241-1249. Date of Electronic Publication: 2016 Dec 07.
DOI:	10.2217/bmm-2016-0210
Abstrakt:	Aim: To evaluate serum growth arrest-specific gene 6 (Gas6) concentration as a biomarker of liver fibrosis progression. Materials & Methods: One hundred and thirteen consecutive patients affected by chronic liver disease underwent transient elastography, Gas6 measurement and, if clinically indicated, liver biopsy. Results: Gas6 concentration was directly correlated to liver stiffness (r = 0.67; p < 0.0001) and was significantly higher in patients with advanced fibrosis (Ishak 4-5; p < 0.001). A plasma concentration <30 ng/ml Gas6 ruled out fibrosis with 84% sensitivity and 56% specificity, while values >42 ng/ml identified severe fibrosis with a sensitivity of 64% and a specificity of 95%; the diagnostic accuracy was comparable to that of transient elastography. Conclusion: Gas6 is a novel biomarker of liver fibrosis, with a potential clinical and pathophysiological relevance.
Databáze:	MEDLINE
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