Noninvasive Microsurgery Using Aptamer-Functionalized Magnetic Microdisks for Tumor Cell Eradication.

Autor: Zamay TN; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 2 Siberian Federal University , Krasnoyarsk, Russia ., Zamay GS; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Belyanina IV; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 2 Siberian Federal University , Krasnoyarsk, Russia ., Zamay SS; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Denisenko VV; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia .; 4 Institute of Computational Modeling, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Kolovskaya OS; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Ivanchenko TI; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Grigorieva VL; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 2 Siberian Federal University , Krasnoyarsk, Russia ., Garanzha IV; 2 Siberian Federal University , Krasnoyarsk, Russia .; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Veprintsev DV; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Glazyrin YE; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia ., Shabanov AV; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Prinz VY; 5 The Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences , Novosibirsk, Russia ., Seleznev VA; 5 The Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences , Novosibirsk, Russia ., Sokolov AE; 6 Institute of Physics, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Prokopenko VS; 7 Krasnoyarsk State Pedagogical University , Krasnoyarsk, Russia ., Kim PD; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia ., Gargaun A; 8 Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa, Canada ., Berezovski MV; 8 Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa, Canada ., Zamay AS; 1 Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University , Krasnoyarsk, Russia .; 3 Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences , Krasnoyarsk, Russia .
Jazyk: angličtina
Zdroj: Nucleic acid therapeutics [Nucleic Acid Ther] 2017 Apr; Vol. 27 (2), pp. 105-114. Date of Electronic Publication: 2016 Dec 06.
DOI: 10.1089/nat.2016.0634
Abstrakt: Magnetomechanical cell disruption using nano- and microsized structures is a promising biomedical technology used for noninvasive elimination of diseased cells. It applies alternating magnetic field (AMF) for ferromagnetic microdisks making them oscillate and causing cell membrane disruption with cell death followed by apoptosis. In this study, we functionalized the magnetic microdisks with cell-binding DNA aptamers and guided the microdisks to recognize cancerous cells in a mouse tumor in vivo. Only 10 min of the treatment with a 100 Hz AMF was enough to eliminate cancer cells from a malignant tumor. Our results demonstrate a good perspective of using aptamer-modified magnetic microdisks for noninvasive microsurgery for tumors.
Databáze: MEDLINE