Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study.

Autor:	Bjørke-Monsen AL; Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway. almo@helse-bergen.no., Ulvik A; Bevital AS, 5021 Bergen, Norway. Arve.Ulvik@uib.no., Nilsen RM; Centre for Clinical Research, Haukeland University Hospital, 5021 Bergen, Norway. Roy.Nilsen@uib.no., Midttun Ø; Bevital AS, 5021 Bergen, Norway. oivind.midttun@bevital.no., Roth C; The Norwegian Institute of Public Health, 0403 Oslo, Norway. Christine.Roth@fhi.no.; Imprints Center for Genetic and Environmental Life Course Studies, Mailman School of Public Health and New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA. Christine.Roth@fhi.no., Magnus P; The Norwegian Institute of Public Health, 0403 Oslo, Norway. Per.Magnus@fhi.no., Stoltenberg C; The Norwegian Institute of Public Health, 0403 Oslo, Norway. camilla.stoltenberg@fhi.no.; Department of Public Health and Primary Health Care, University of Bergen, 5007 Bergen, Norway. camilla.stoltenberg@fhi.no., Vollset SE; The Norwegian Institute of Public Health, 0403 Oslo, Norway. SteinEmil.Vollset@fhi.no.; Department of Public Health and Primary Health Care, University of Bergen, 5007 Bergen, Norway. SteinEmil.Vollset@fhi.no., Reichborn-Kjennerud T; The Norwegian Institute of Public Health, 0403 Oslo, Norway. Ted.Reichborn-Kjennerud@fhi.no.; Institute of Clinical Medicine, University of Oslo, 0313 Oslo, Norway. Ted.Reichborn-Kjennerud@fhi.no., Ueland PM; Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway. per.ueland@ikb.uib.no.; Department of Clinical Science, University of Bergen, 5007 Bergen, Norway. per.ueland@ikb.uib.no.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2016 Nov 30; Vol. 8 (12). Date of Electronic Publication: 2016 Nov 30.
DOI:	10.3390/nu8120776
Abstrakt:	Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin ( p < 0.001), and associated with increased neopterin and KTR levels ( p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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