Age and gender interactions in white matter of schizophrenia and obsessive compulsive disorder compared to non-psychiatric controls: commonalities across disorders.

Autor: Hawco C; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada. colin.hawco@camh.ca.; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada. colin.hawco@camh.ca., Voineskos AN; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Radhu N; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada.; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada., Rotenberg D; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada., Ameis S; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Backhouse FA; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada.; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada., Semeralul M; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada., Daskalakis ZJ; Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Unit 4-1, Office 125, 1001 Queen Street West, Toronto, ON, M6J 1H4, Canada.; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2017 Dec; Vol. 11 (6), pp. 1836-1848.
DOI: 10.1007/s11682-016-9657-8
Abstrakt: Schizophrenia (SCZ) and obsessive-compulsive disorder (OCD) are psychiatric disorders with abnormalities in white matter structure. These disorders share high comorbidity and family history of OCD is a risk factor for SCZ which suggests some shared neurobiology. White matter was examined using diffusion tensor imaging in relativity large samples of SCZ (N = 48), OCD (N = 38) and non-psychiatric controls (N = 45). Fractional anisotropy (FA) was calculated and tract based spatial statistics were used to compare groups. In a whole brain analysis, SCZ and OCD both showed small FA reductions relative to controls in the corpus callosum. Both SCZ and OCD showed accelerated reductions in FA with age; specifically in the left superior longitudinal fasciculus in OCD, while the SCZ group demonstrated a more widespread pattern of FA reduction. Patient groups did not differ from each other in total FA or age effects in any regions. A general linear model using 13 a-priori regions of interest showed marginal group, group*gender, and group*age interactions. When OCD and SCZ groups were analyzed together, these marginal effects became significant (p < 0.05), suggesting commonalities exist between these patient groups. Overall, our results demonstrate a similar pattern of accelerated white matter decline with age and greater white matter deficit in females in OCD and SCZ, with overlap in the spatial pattern of deficits. There was no evidence for statistical differences in overall white matter between OCD and SCZ. Taken together, the results support the notion of shared neurobiology in SCZ and OCD.
Databáze: MEDLINE
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