Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System.
| Autor: | Spurlock CF 3rd; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and., Crooke PS 3rd; Department of Mathematics, Vanderbilt University, Nashville, TN 37232., Aune TM; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and tom.aune@vanderbilt.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Dec 15; Vol. 197 (12), pp. 4509-4517. |
| DOI: | 10.4049/jimmunol.1600970 |
| Abstrakt: | The central dogma of molecular biology states that DNA makes RNA makes protein. Discoveries over the last quarter of a century found that the process of DNA transcription into RNA gives rise to a diverse array of functional RNA species, including genes that code for protein and noncoding RNAs. For decades, the focus has been on understanding how protein-coding genes are regulated to influence protein expression. However, with the completion of the Human Genome Project and follow-up ENCODE data, it is now appreciated that only 2-3% of the genome codes for protein-coding gene exons and that the bulk of the transcribed genome, apart from ribosomal RNAs, is at the level of noncoding RNA genes. In this article, we focus on the biogenesis and regulation of a distinct class of noncoding RNA molecules termed long, noncoding RNAs in the context of the immune system. Competing Interests: Competing financial interests: The authors declare no competing financial interests (Copyright © 2016 by The American Association of Immunologists, Inc.) |
| Databáze: | MEDLINE |
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