Selective Blockade of α 2 -Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium.

Autor: Zefirov TL; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia. zefirovtl@mail.ru., Khisamieva LI; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia., Ziyatdinova NI; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia., Zefirov AL; Department of Normal Physiology, Kazan State Medical University, Kazan, the Republic of Tatarstan, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Dec; Vol. 162 (2), pp. 177-179. Date of Electronic Publication: 2016 Dec 02.
DOI: 10.1007/s10517-016-3569-x
Abstrakt: The study examined the dose-dependent effects of selective antagonists of α 2A/D -, α 2B -, and α 2C - adrenoceptors applied in concentrations of 10 -9 -10 -5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α 2 -adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α 2A/D - and α 2C -adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α 2B -Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.
Databáze: MEDLINE
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