The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia.

Autor: de Brito RC; Institute of Integral Medicine Professor Fernando, Figueira (IMIP), Pediatrics, Rua Dona Benvinda de Farias 159, apt 1101, Boa Viagem, Recife, Pernambuco, Brazil. moraesdebrito@gmail.com., Lucena-Silva N; Institute of Integral Medicine Professor Fernando Figueira (IMIP), Oncology and Aggeu Magalhães Research Center, Fiocruz-PE, Immunology, Recife, Brazil., Torres LC; Institute of Integral Medicine Professor Fernando, Figueira, IMIP, Translational Medicine Laboratory, Recife, Brazil., Luna CF; Aggeu Magalhães Research Center, Fiocruz-PE, Public Health, Recife, Brazil., Correia JB; Institute of Integral Medicine Professor Fernando, Figueira, IMIP, Translational Medicine Laboratory, Recife, Brazil., da Silva GA; Federal University of Pernambuco, Pediatrics, Recife, Brazil.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2016 Dec 01; Vol. 16 (1), pp. 170. Date of Electronic Publication: 2016 Dec 01.
DOI: 10.1186/s12890-016-0324-z
Abstrakt: Background: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity.
Methods: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines.
Results: At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025). The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively.
Conclusions: The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity definition and evaluation of recovery in patients with pneumonia.
Databáze: MEDLINE
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