Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.
| Autor: | Ebadifar A; Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ameli N; Department of Orthodontic, Dental School, Semnan University of Medical Sciences, Semnan, Iran., KhorramKhorshid HR; Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Kamali K; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Zeinabadi MS; Department of Pediatric, Dental School, Semnan University of Medical Sciences, Semnan, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2016 Aug 01; Vol. 21, pp. 59. Date of Electronic Publication: 2016 Aug 01 (Print Publication: 2016). |
| DOI: | 10.4103/1735-1995.187307 |
| Abstrakt: | Background: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase ( MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. Materials and Methods: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed. Results: Genotype consistency was not statistically significant in both C677T and A1298C gene variants ( P > 0.05). Conclusion: Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children. |
| Databáze: | MEDLINE |
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