Separation of 44 Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44 Ti/ 44 Sc generator system.

Autor: Radchenko V; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Meyer CAL; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Engle JW; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Naranjo CM; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Unc GA; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Mastren T; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Brugh M; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Birnbaum ER; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., John KD; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Nortier FM; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA., Fassbender ME; Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA. Electronic address: mifa@lanl.gov.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2016 Dec 16; Vol. 1477, pp. 39-46. Date of Electronic Publication: 2016 Nov 24.
DOI: 10.1016/j.chroma.2016.11.047
Abstrakt: Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18 F, due to its favorable decay parameters. One source of 44g Sc is the long-lived parent nuclide 44 Ti (half-life 60.0 a). A 44 Ti/ 44g Sc generator would have the ability to provide radionuclidically pure 44g Sc on a daily basis. The production of 44 Ti via the 45 Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44 Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Results indicate that ZR resin in HCl media represents an effective 44 Ti/ 44g Sc separation system.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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