| Autor: |
Khadrawy YA; Medical Physiology Department, Medical Division, National Research Center, Giza, Egypt. yaserask@yahoo.com., Mourad IM, Mohammed HS, Noor NA, Aboul Ezz HS |
| Jazyk: |
angličtina |
| Zdroj: |
General physiology and biophysics [Gen Physiol Biophys] 2017 Jan; Vol. 36 (1), pp. 99-108. Date of Electronic Publication: 2016 Nov 30. |
| DOI: |
10.4149/gpb_2016031 |
| Abstrakt: |
The aim of the present work was to investigate the neurochemical changes induced in the cerebellum of rat model of Parkinson's disease (PD). Rats were divided into two groups; control and rat model of PD induced by the intrastriatal injection of rotenone. As compared to control, a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine were observed in the cerebellum of rat model of PD. This was associated with a significant increase in lipid peroxidation, nitric oxide and tumor necrosis factor-α and a significant decrease in reduced glutathione. A significant decrease in acetylcholinesterase and a significant increase in Na+,K+-ATPase were recorded in the cerebellum of rat model of PD. In addition the cerebellar sections from rat model of PD showed marked necrosis of Purkinje cells, irregular damaged cells, cytoplasmic shrinkage, necrosis and perineuronal vacuolation. The present results indicate that the disturbance in the balance between the excitatory and inhibitory amino acids may have a role in the pathogenesis of PD. According to the present neurochemical and histopathological changes, the cerebellum should be taken into consideration during the treatment of PD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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