Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Autor:	Luque RM; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.; Hospital Universitario Reina Sofía (HURS), Córdoba, Spain.; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Campus de Excelencia Internacional Agroalimentario (ceiA3), Córdoba, Spain., Cordoba-Chacon J; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.; Hospital Universitario Reina Sofía (HURS), Córdoba, Spain.; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Campus de Excelencia Internacional Agroalimentario (ceiA3), Córdoba, Spain.; Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago and Jesse Brown Veteran Affairs Medical Center, Research and Development Division, Chicago, IL, USA., Pozo-Salas AI; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.; Hospital Universitario Reina Sofía (HURS), Córdoba, Spain.; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Campus de Excelencia Internacional Agroalimentario (ceiA3), Córdoba, Spain., Porteiro B; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., de Lecea L; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA., Nogueiras R; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Gahete MD; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.; Hospital Universitario Reina Sofía (HURS), Córdoba, Spain.; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Campus de Excelencia Internacional Agroalimentario (ceiA3), Córdoba, Spain., Castaño JP; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.; Hospital Universitario Reina Sofía (HURS), Córdoba, Spain.; CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain.; Campus de Excelencia Internacional Agroalimentario (ceiA3), Córdoba, Spain.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2016 Nov 30; Vol. 6, pp. 37992. Date of Electronic Publication: 2016 Nov 30.
DOI:	10.1038/srep37992
Abstrakt:	Somatostatin (SST) and cortistatin (CORT) regulate numerous endocrine secretions and their absence [knockout (KO)-models] causes important endocrine-metabolic alterations, including pituitary dysregulations. We have demonstrated that the metabolic phenotype of single or combined SST/CORT KO-models is not drastically altered under normal conditions. However, the biological actions of SST/CORT are conditioned by the metabolic-status (e.g. obesity). Therefore, we used male/female SST- and CORT-KO mice fed low-fat (LF) or high-fat (HF) diet to explore the interplay between SST/CORT and obesity in the control of relevant pituitary-axes and whole-body metabolism. Our results showed that the SST/CORT role in the control of GH/prolactin secretions is maintained under LF- and HF-diet conditions as SST-KOs presented higher GH/prolactin-levels, while CORT-KOs displayed higher GH- and lower prolactin-levels than controls under both diets. Moreover, the impact of lack of SST/CORT on the metabolic-function was gender- and diet-dependent. Particularly, SST-KOs were more sensitive to HF-diet, exhibiting altered growth and body-composition (fat/lean percentage) and impaired glucose/insulin-metabolism, especially in males. Conversely, only males CORT-KO under LF-diet conditions exhibited significant alterations, displaying higher glucose-levels and insulin-resistance. Altogether, these data demonstrate a tight interplay between SST/CORT-axis and the metabolic status in the control of endocrine/metabolic functions and unveil a clear dissociation of SST/CORT roles.
Databáze:	MEDLINE
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