Emerging biopharmaceuticals from marine actinobacteria.

Autor: Hassan SS; Ocean College, Zhejiang University, Hangzhou 310058, China. Electronic address: Hassan13@zju.edu.cn., Anjum K; Ocean College, Zhejiang University, Hangzhou 310058, China., Abbas SQ; Faculty of Pharmacy, Gomal University D.I. Khan, K.P.K 29050, Pakistan., Akhter N; Ocean College, Zhejiang University, Hangzhou 310058, China., Shagufta BI; Department of Zoology, Kohat University of Science and Technology (KUST), K.P.K 26000, Pakistan., Shah SA; Ocean College, Zhejiang University, Hangzhou 310058, China., Tasneem U; Department of Microbiology, Kohat University of Science and Technology (KUST), K.P.K 26000, Pakistan.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2017 Jan; Vol. 49, pp. 34-47. Date of Electronic Publication: 2016 Nov 22.
DOI: 10.1016/j.etap.2016.11.015
Abstrakt: Actinobacteria are quotidian microorganisms in the marine world, playing a crucial ecological role in the recycling of refractory biomaterials and producing novel secondary metabolites with pharmaceutical applications. Actinobacteria have been isolated from the huge area of marine organisms including sponges, tunicates, corals, mollusks, crabs, mangroves and seaweeds. Natural products investigation of the marine actinobacteria revealed that they can synthesize numerous natural products including alkaloids, polyketides, peptides, isoprenoids, phenazines, sterols, and others. These natural products have a potential to provide future drugs against crucial diseases like cancer, HIV, microbial and protozoal infections and severe inflammations. Therefore, marine actinobacteria portray as a pivotal resource for marine drugs. It is an upcoming field of research to probe a novel and pharmaceutically important secondary metabolites from marine actinobacteria. In this review, we attempt to summarize the present knowledge on the diversity, chemistry and mechanism of action of marine actinobacteria-derived secondary metabolites from 2007 to 2016.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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