Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.

Autor:	Nozawa M; Center for Information Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.; Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.; Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minamiosawa, Hachioji, Tokyo 192-0397, Japan., Onizuka K; Center for Information Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Fujimi M; Center for Information Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Ikeo K; Center for Information Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.; Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Gojobori T; Center for Information Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.; King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Biological and Environmental Science and Engineering, 4700 KAUST, Thuwal 23955-6900; Kingdom of Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2016 Nov 29; Vol. 7, pp. 13659. Date of Electronic Publication: 2016 Nov 29.
DOI:	10.1038/ncomms13659
Abstrakt:	Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu