Diterpenes as lead molecules against neglected tropical diseases.

Autor: Barros de Alencar MV; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., de Castro E Sousa JM; Department of Biological Sciences, Federal University of Piauí, Picos, (Piauí), 64.607-670, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Rolim HM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., de Medeiros MD; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Cerqueira GS; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Postgraduate Program in Biotechnology, Biotechnology and Biodiversity Center for Research (BIOTEC), Federal University of Piauí (LAFFEX), Parnaíba, Piauí, 64.218-470, Brazil., de Castro Almeida FR; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Citó AM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Ferreira PM; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Lopes JA; Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., de Carvalho Melo-Cavalcante AA; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Islam MT; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Pharmacy, Southern University Bangladesh, Mehedibag, Chittagong, 4000, Bangladesh.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2017 Feb; Vol. 31 (2), pp. 175-201. Date of Electronic Publication: 2016 Nov 29.
DOI: 10.1002/ptr.5749
Abstrakt: Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.
(Copyright © 2016 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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