Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome.

Autor: Snijders AM; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Langley SA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Kim YM; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Brislawn CJ; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Noecker C; Department of Genome Sciences, University of Washington, Seattle, Washington 98105, USA., Zink EM; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Fansler SJ; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Casey CP; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Miller DR; Systems Genetics Core Facility, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Huang Y; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Karpen GH; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA., Celniker SE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Brown JB; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Borenstein E; Department of Genome Sciences, University of Washington, Seattle, Washington 98105, USA.; Department of Computer Science and Engineering, University of Washington, Seattle, Washington 98195, USA.; Santa Fe Institute, Santa Fe, New Mexico 87501, USA., Jansson JK; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Metz TO; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA., Mao JH; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2016 Nov 28; Vol. 2, pp. 16221. Date of Electronic Publication: 2016 Nov 28.
DOI: 10.1038/nmicrobiol.2016.221
Abstrakt: Although the gut microbiome plays important roles in host physiology, health and disease 1 , we lack understanding of the complex interplay between host genetics and early life environment on the microbial and metabolic composition of the gut. We used the genetically diverse Collaborative Cross mouse system 2 to discover that early life history impacts the microbiome composition, whereas dietary changes have only a moderate effect. By contrast, the gut metabolome was shaped mostly by diet, with specific non-dietary metabolites explained by microbial metabolism. Quantitative trait analysis identified mouse genetic trait loci (QTL) that impact the abundances of specific microbes. Human orthologues of genes in the mouse QTL are implicated in gastrointestinal cancer. Additionally, genes located in mouse QTL for Lactobacillales abundance are implicated in arthritis, rheumatic disease and diabetes. Furthermore, Lactobacillales abundance was predictive of higher host T-helper cell counts, suggesting an important link between Lactobacillales and host adaptive immunity.
Databáze: MEDLINE