Diabetic Macular Ischemia Diagnosis: Comparison between Optical Coherence Tomography Angiography and Fluorescein Angiography.

Autor: Garcia JM; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil., Lima TT; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil., Louzada RN; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil., Rassi AT; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil., Isaac DL; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil., Avila M; Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
Jazyk: angličtina
Zdroj: Journal of ophthalmology [J Ophthalmol] 2016; Vol. 2016, pp. 3989310. Date of Electronic Publication: 2016 Nov 07.
DOI: 10.1155/2016/3989310
Abstrakt: Purpose . To compare fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia (DMI). Methods . The Wilcoxon signed-rank test was used to compare area measurements and p values of <0.05 were considered statistically significant. FA and OCTA images were independently graded by 2 observers that reached agreement regarding quantitative DMI according established protocols. The ischemic area was divided into "large" macular ischemia (superior to 0.32 mm 2 ) and "small" (inferior to 0.32 mm 2 ) groups. Quantitative analyses of the FAZ were performed using custom software. Results . Thirty-four eyes from 34 diabetic patients were enrolled. Subjects with DMI presented a mean area on FA and OCTA of 0.68 ± 0.53 mm 2 and 0.58 ± 0.35 mm 2 , respectively ( p = 0.1374). Patients without DMI presented a mean area on FA and OCTA of 0.19 ± 0.67 mm 2 and 0.20 ± 0.79 mm 2 , respectively ( p = 0.9594). The ICC for the FAZ measurements between the 2 observers on FA and OCTA was 0.96 and 0.92, respectively. Conclusion . OCTA represents a novel technique for the diagnosis of DMI and it may become an alternative to FA for this purpose.
Competing Interests: All authors have no financial disclosures.
Databáze: MEDLINE
Externí odkaz: