[Preparation and pharmacologic activity of N-oxides of 4'-(benzotriazol-2-yl-phenylalkanoic and -phenoxyalkanoic acids].

Autor: Boido A; Istituto di Scienze Farmaceutiche, Università di Genova., Vazzana I, Sparatore F, Cappello B, Diurno V, Matera C, Marrazzo R, Russo S, Cenicola ML, Marmo E
Jazyk: italština
Zdroj: Farmaco (Societa chimica italiana : 1989) [Farmaco] 1989 Mar; Vol. 44 (3), pp. 257-77.
Abstrakt: A number of N-oxides of 4'-(benzotriazol-2-yl)-phenylalkanoic and -phenoxyalkanoic acids bearing various substituents on position 6 of benzotriazole together with 4'-(benzotriazol-2-yl) phenylacetic acid were prepared and subjected to a wide pharmacological screening. Several compounds exhibited significant antiinflammatory and diuretic activities, while one was endowed with antihypertensive activity.
Databáze: MEDLINE