Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease.

Autor: Shreve LA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Velisar A; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Malekmohammadi M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Koop MM; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Trager M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Quinn EJ; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Hill BC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Blumenfeld Z; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Kilbane C; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Mantovani A; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Henderson JM; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Brontë-Stewart H; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: hbs@stanford.edu.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2017 Jan; Vol. 128 (1), pp. 128-137. Date of Electronic Publication: 2016 Nov 10.
DOI: 10.1016/j.clinph.2016.10.095
Abstrakt: Objective: Determine the incidence of resting state oscillations in alpha/beta, high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large cohort in Parkinson's disease (PD).
Methods: Intra-operative local field potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD subjects, data from 74 subjects were included in the analysis.
Results: Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. Alpha/beta oscillations (P<0.01) and PAC were stronger in the more affected (MA) hemisphere (P=0.03). Alpha/beta oscillations were primarily found in 13-20Hz (low beta). Beta and HFO frequencies with the greatest coupling, were positively correlated (P=0.001). Tremor attenuated alpha (P=0.002) and beta band oscillations (P<0.001).
Conclusions: STN alpha/beta band oscillations and PAC were evident in ⩾98% cases and were greater in MA hemisphere. Resting tremor attenuated underlying alpha/beta band oscillations.
Significance: Beta band LFP power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a kinematic classifier in tremor dominant PD.
(Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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