A systematic review of risks and benefits with nipple-areola-reconstruction.

Autor: Kristoffersen CM; a Department of Plastic and Reconstructive Surgery , Haukeland University Hospital , Bergen , Norway., Seland H; a Department of Plastic and Reconstructive Surgery , Haukeland University Hospital , Bergen , Norway., Hansson E; b Department of Plastic and Reconstructive Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden.; c Department of Clinical Sciences, Malmö, Lund University , Lund , Sweden.
Jazyk: angličtina
Zdroj: Journal of plastic surgery and hand surgery [J Plast Surg Hand Surg] 2017 Oct; Vol. 51 (5), pp. 287-295. Date of Electronic Publication: 2016 Nov 25.
DOI: 10.1080/2000656X.2016.1251935
Abstrakt: Background: Most women who have their breast reconstructed are offered NAC reconstruction. Nonetheless, it is unclear what scientific evidence there is for the procedure. The aims of the present systematic review were to evaluate the quality of evidence for benefits and risks with NAC reconstruction, and to examine the evidence for different techniques.
Methods: Relevant databases were searched. Inclusion criteria were controlled studies comprising ≥20 patients and a case series of ≥50 patients. Included articles had to meet criteria defined in a PICO (Patient, Intervention, Comparison, and Outcome). Data extraction and collection were performed according to the QUADAS tool. The level of evidence of the selected articles was assessed according to the Oxford Centre for Evidence-Based Medicine 2009 guidelines, and total evidence for the different research questions was graded according to the GRADE-system.
Results: A total of 362 abstracts were retrieved following the search. Of these 325 did not meet the inclusion criteria and were excluded, leaving 37 studies to be included in the review. Among these, 36 were case series and one a small randomised non-blinded study Conclusions: The existing quality of evidence for risks and benefits of the operation is very low. It is unclear what the complication frequencies are after the reconstruction, and what effect on quality-of-life the operation has. Prospective studies of high quality are needed to evaluate the health effects and risks with NAC reconstruction.
Databáze: MEDLINE
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