Elevated adiponectin but varied response in circulating leptin levels to falciparum malaria in type 2 diabetics and non-diabetic controls.

Autor:	Acquah S; Department of Medical Biochemistry, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana. Electronic address: s.acquah@uccsms.edu.gh., Eghan BA Jnr; Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Boampong JN; Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
Jazyk:	angličtina
Zdroj:	Biomedical journal [Biomed J] 2016 Oct; Vol. 39 (5), pp. 346-353. Date of Electronic Publication: 2016 Oct 27.
DOI:	10.1016/j.bj.2016.09.003
Abstrakt:	Background: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. Methods: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria in a 2-year prospective study. Also, waist circumference (WC), weight, height and hip circumference were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were computed. Results: At baseline, diabetics had significantly (p < 0.05) higher WC and BMI but lower WHR, leptin and adiponectin levels. Baseline leptin correlated positively with WC (r = 0.633; p < 0.001) and BMI (r = 0.63; p < 0.001) in diabetics but only BMI (0.562; p < 0.001) in non-diabetic controls. Baseline leptin and adiponectin correlated positively (r = 0.249; p = 0.029) in non-diabetic respondents only. Adiponectin correlated negatively with WC (r = -0.58; p = 0.006) in diabetic males only. During malaria, mean levels of leptin and adiponectin were comparable (p > 0.05) between diabetics and controls. However, compared to baseline levels, significant (p < 0.001) elevation of adiponectin was found in both study groups. In respect of leptin, significant (p < 0.001) rise but decline was observed in diabetics and controls respectively. Malaria-induced leptin correlated negatively with adiponectin (r = -0.694; p < 0.001) in non-diabetic controls only. Conclusion: Diabetics and controls exhibited increased adiponectin levels due to falciparum malaria but differed in response in terms of leptin levels. (Copyright © 2016 Chang Gung University. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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