Can an Intervention with Testosterone and Nutritional Supplement Improve the Frailty Level of Under-Nourished Older People?
| Autor: | Theou O; Olga Theou, Dalhousie University and Nova Scotia Health Authority, Suite 1313, 5955 Veterans' Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada. Tel: 902-473-4846, e-mail: otheou@alumni.uwo.ca., Chapman I, Wijeyaratne L, Piantadosi C, Lange K, Naganathan V, Hunter P, Cameron ID, Rockwood K, Visvanathan R |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of frailty & aging [J Frailty Aging] 2016; Vol. 5 (4), pp. 247-252. |
| DOI: | 10.14283/jfa.2016.108 |
| Abstrakt: | Objective: To examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. Design: Randomized controlled trial. Setting/participants: 53 community-dwelling, undernourished men and women aged >65 years from South Australia, Victoria and New South Wales. Intervention: Intervention group received oral testosterone undecanoate and a high calorie supplement (2108-2416 kJ/day) whereas the control group received placebo testosterone and low calorie supplement (142-191 kJ/day). Measurements: Frailty was operationalized using three frailty indices (FI-lab, FI-self-report, FI-combined) and the frailty phenotype. Results: There were no significant differences in changes in frailty scores at either 6 or 12 months follow up between the two treatment groups for all scales. Participants at the intervention group were 4.8 times more likely to improve their FI-combined score at both time points compared to the placebo group. Conclusion: A testosterone and a high calorie nutritional supplement intervention did not improve the frailty levels of under-nourished older people. Even so, when frailty was measured using a frailty index combining self-reported and lab data we found that participants who received the intervention were more likely to show persistent improvement in their frailty scores. |
| Databáze: | MEDLINE |
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