Muscular fitness and metabolic and inflammatory biomarkers in adolescents: Results from LabMed Physical Activity Study.

Autor: Agostinis-Sobrinho CA; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Moreira C; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Abreu S; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Lopes L; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.; Research Centre on Child Studies (CIEC), Institute of Education, University of Minho, Braga, Portugal., Sardinha LB; Exercise and Health Laboratory, CIPER, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal., Oliveira-Santos J; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Oliveira A; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Mota J; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal., Santos R; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.; Early Start Research Institute, Faculty of Social Sciences, School of Education, University of Wollongong, Wollongong, NSW, Australia.; University Institute of Maia, Maia, Portugal.
Jazyk: angličtina
Zdroj: Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2017 Dec; Vol. 27 (12), pp. 1873-1880. Date of Electronic Publication: 2016 Nov 23.
DOI: 10.1111/sms.12805
Abstrakt: This study aimed to evaluate the associations between muscular fitness and inflammatory biomarkers and to investigate the relationship between muscular fitness and selected clustered inflammatory biomarkers in adolescents. This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12-18 years. Handgrip strength and standing long jump tests assessed MF. Continuous scores of clustered inflammatory biomarkers (sum of Z-scores of C-reactive protein [CRP], C3, C4, fibrinogen, and leptin); metabolic risk factor (MRF) score (sum of Z-scores of SBP, triglycerides, ratio total cholesterol [TC]/HDL, HOMA-IR, and waist circumference [WC]) were computed. Regression analyses showed an inverse association between muscular fitness score (β=-.204; P<.021) and clustered score of inflammatory biomarkers, adjusted for age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness (CRF), MRF score, and body fat. Analysis of covariance showed that adolescents with an adverse inflammatory profile with low levels of muscular fitness exhibit the poorest MRF score (F 3,525 =6.461; P<.001), adjusted for age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, CRF, and body fatness. The inflammatory state seems to explain a significant part of the highest MRF score and in adolescents with high inflammatory status and low muscular strength.
(© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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