High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy.

Autor:	Zweiphenning WJ; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., van 't Klooster MA; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., van Diessen E; Brain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., van Klink NE; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Huiskamp GJ; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Gebbink TA; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Leijten FS; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Gosselaar PH; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Otte WM; Brain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands; Stichting Epilepsie Instellingen Nederland, Heemstede, P.O. box 540, 2130 AM Hoofddorp, The Netherlands., Stam CJ; Department of Clinical Neurophysiology, Neuroscience Campus Amsterdam, VU University Medical Center, Postbus 7057, 1007 MB Amsterdam, The Netherlands., Braun KP; Brain Center Rudolf Magnus, Department of Pediatric Neurology, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands., Zijlmans GJ; Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, P.O. box 85500, 3508 GA Utrecht, The Netherlands; Stichting Epilepsie Instellingen Nederland, Heemstede, P.O. box 540, 2130 AM Hoofddorp, The Netherlands.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2016 Nov 04; Vol. 12, pp. 928-939. Date of Electronic Publication: 2016 Nov 04 (Print Publication: 2016).
DOI:	10.1016/j.nicl.2016.09.014
Abstrakt:	Objective: High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and 'baseline' functional connectivity within EEG networks, especially in the high frequency bands. Methods: We marked FRs, ripples (80-250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy. We assessed 'baseline' functional connectivity in epochs free of epileptiform events within these recordings, using the phase lag index. We computed the Eigenvector Centrality (EC) per channel in the FR and gamma band network. We compared EC between channels that did or did not show events at other moments in time. Results: FR-band EC was higher in channels with than without spikes. Gamma-band EC was lower in channels with ripples and FRs. Conclusions: We confirmed previous findings of functional isolation in the gamma-band and found a first proof of functional integration in the FR-band network of channels covering presumed epileptogenic tissue. Significance: 'Baseline' high-frequency network parameters might help intra-operative recognition of epileptogenic tissue without the need for waiting for events. These findings can increase our understanding of the 'architecture' of epileptogenic networks and help unravel the pathophysiology of HFOs.
Databáze:	MEDLINE
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