Peculiar Aspects in Influence of α 1 -Adrenoceptor Stimulation on Isolated Rat Heart.

Autor: Zefirov TL; Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia. zefirovtl@mail.ru., Khabibrakhmanov II; Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia., Ziyatdinova NI; Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia., Zefirov AL; Department of Normal Physiology, Kazan Federal Medical University, Kazan, the Republic of Tatarstan, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Nov; Vol. 162 (1), pp. 4-6. Date of Electronic Publication: 2016 Nov 22.
DOI: 10.1007/s10517-016-3530-z
Abstrakt: The study examined the effect of α 1 -adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α 1 -adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
Databáze: MEDLINE
Externí odkaz: