Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life.
| Autor: | Galati DF; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: domenico.galati@ucdenver.edu., Mitchell BJ; Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Pearson CG; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Developmental cell [Dev Cell] 2016 Nov 21; Vol. 39 (4), pp. 387-389. |
| DOI: | 10.1016/j.devcel.2016.11.006 |
| Abstrakt: | Centrioles acquire subdistal appendages (sDAPs) during primary cilium formation. In this issue of Developmental Cell, Mazo et al. (2016) demonstrate that sDAPs keep cilia submerged within deep membrane invaginations. When sDAPs and centrosome cohesion are disrupted, cilia surface to the plasma membrane, which may alter mechanical and chemical signal transduction. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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