Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS).

Autor: Mercadante S; Anesthesia and Intensive Care and Pain Relief and Supportive Care, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy. terapiadeldolore@lamaddalenanet.it., Marchetti P; Molecular and Clinical Medicine, Medical Oncology, La Sapienza University of Rome, Rome, Italy., Cuomo A; Anesthesiology, Resuscitation, and Pain Therapy Department, National Cancer Institute, IRCCS Foundation Pascale, Naples, Italy., Caraceni A; Palliative Care, Pain Therapy and Rehabilitation, National Cancer Institute IRCCS Foundation, Milan, Italy., Mediati RD; Palliative Care and Pain Therapy Unit, Careggi Hospital, Florence, Italy., Mammucari M; Primary Care Unit, ASL RM1, Rome, Italy., Natoli S; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.; Department of Emergency, Admission and Critical Area, Policlinic of Tor Vergata, Rome, Italy., Lazzari M; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.; Department of Emergency, Admission and Critical Area, Policlinic of Tor Vergata, Rome, Italy., Dauri M; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.; Department of Emergency, Admission and Critical Area, Policlinic of Tor Vergata, Rome, Italy., Airoldi M; 2nd Medical Oncology Division, Città della Salute e della Scienza Hospital of Turin, Turin, Italy., Azzarello G; Medical Specialties Department, Oncology and Oncologic Hematology, ASL 13 Mirano, Venice, Italy., Bandera M; Medical Oncology Unit, Ospedale di Circolo e Fondazione Macchi Hospital, Varese, Italy., Blasi L; Medical Oncology Unit, ARNAS Ospedale Civico, Di Cristina, Benfratelli, Palermo, Italy., Cartenì G; Medical Oncology, A.O.R.N. Cardarelli, Naples, Italy., Chiurazzi B; Medical Oncology, A.O.R.N. Cardarelli, Naples, Italy., Costanzo BVP; Palliative Care Unit, SAMO ONLUS, Catania, Italy., Degiovanni D; Palliative Care Unit, ASLAL, Casale Monferrato, Italy., Fusco F; Palliative Care Unit, Department of Primary and Community Care, ASL3 Genovese, Genoa, Italy., Guardamagna V; Palliative Care and Pain Therapy Unit, European Oncology Institute IRCCS, Milan, Italy., Iaffaioli V; Abdominal Medical Oncology, National Cancer Institute, IRCCS Foundation Pascale, Naples, Italy., Liguori S; Palliative Care and Pain Therapy Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy., Lorusso V; Medical Oncology Unit, National Cancer Research Centre 'Giovanni Paolo II', Bari, Italy., Mameli S; Pain Therapy Unit, 'A. Businco' Hospital, ASL 8, Cagliari, Italy., Mattioli R; Medical Oncology Unit, S. Croce Hospital, Fano, Pesaro, Italy., Mazzei T; Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy., Melotti RM; Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy., Menardo V; Pain Therapy, S. Croce e Carle, Hospital Cuneo, Cuneo, Italy., Miotti D; Palliative Care Unit, Salvatore Maugeri-IRCCS Foundation, Pavia, Italy., Moroso S; Medical Oncology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy., De Santis S; Palliative Care and Oncologic Pain Service, S. Camillo-Forlanini Hospital, Rome, Italy., Orsetti R; Pain Medicine Unit, S. Camillo-Forlanini Hospital, Rome, Italy., Papa A; Pain Relief, A.O. Dei Colli, Monaldi Hospital, Naples, Italy., Ricci S; Division of Medical Oncology, Department of Oncology, S. Chiara University Hospital, Pisa, Italy., Sabato AF; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.; Department of Emergency, Admission and Critical Area, Policlinic of Tor Vergata, Rome, Italy., Scelzi E; Medical Oncology, Castelfranco Veneto Hospital, Treviso, Italy., Sofia M; Department of Palliative Care with Hospice and Pain Therapy Unit, 'G.Salvini' Hospital, Garbagnate Milanese, Milan, Italy., Tonini G; Department of Medical Oncology, Campus Bio-Medico University of Rome, Rome, Italy., Aielli F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Valle A; Palliative Care, FARO Foundation, Turin, Italy.
Jazyk: angličtina
Zdroj: Advances in therapy [Adv Ther] 2017 Jan; Vol. 34 (1), pp. 120-135. Date of Electronic Publication: 2016 Nov 21.
DOI: 10.1007/s12325-016-0440-4
Abstrakt: Introduction: An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here.
Methods: Thirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity.
Results: Background pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids.
Conclusions: These preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients' satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients.
Funding: Molteni Farmaceutici, Italy.
Databáze: MEDLINE