In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates.

Autor:	Bordallo-Cardona MÁ; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Escribano P; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain pilar.escribano.martos@gmail.com jguineaortega@yahoo.es.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., de la Pedrosa EG; Clinical Microbiology, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Biomédica, Madrid, Spain.; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain., Marcos-Zambrano LJ; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Cantón R; Clinical Microbiology, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Biomédica, Madrid, Spain.; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain., Bouza E; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain., Guinea J; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain pilar.escribano.martos@gmail.com jguineaortega@yahoo.es.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Jan 24; Vol. 61 (2). Date of Electronic Publication: 2017 Jan 24 (Print Publication: 2017).
DOI:	10.1128/AAC.01542-16
Abstrakt:	We assessed the in vitro susceptibility of five echinocandin-susceptible Candida glabrata isolates after exposure to micafungin. The direct exposure to plates at different micafungin concentrations resulted in the inhibition of growth at 0.062 μg/ml. The progressive exposure was performed on plates using 0.031 μg/ml of micafungin and sequential propagation on plates containing the next 2-fold concentration; the MICs of micafungin and anidulafungin increased sequentially, and all the isolates became echinocandin resistant, showing fks2 mutations. (Copyright © 2017 American Society for Microbiology.)
Databáze:	MEDLINE
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