Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder.

Autor: Saad K; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt., Abdel-Rahman AA; Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt., Elserogy YM; Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt., Al-Atram AA; Department of Psychiatry, College of Medicine, Almajmaah University, Riyadh, Saudi Arabia., El-Houfey AA; Department of Community Health Nursing, Assiut University, Assiut, Egypt., Othman HA; Department of Clinical Pathology, Aswan University, Aswan, Egypt., Bjørklund G; Council for Nutritional and Environmental Medicine, Mo i Rana, Norway., Jia F; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, Changchun, China., Urbina MA; Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.; Departamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Concepción, Chile., Abo-Elela MGM; Department of Pediatrics, Qena Faculty of Medicine, South Valley University, Qena, Egypt., Ahmad FA; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt., Abd El-Baseer KA; Department of Pediatrics, Qena Faculty of Medicine, South Valley University, Qena, Egypt., Ahmed AE; Department of Pediatrics, Qena Faculty of Medicine, South Valley University, Qena, Egypt., Abdel-Salam AM; Department of Pharmaceutics and Industrial Pharmacy, Alazhar University, Assiut, Egypt.
Jazyk: angličtina
Zdroj: Journal of child psychology and psychiatry, and allied disciplines [J Child Psychol Psychiatry] 2018 Jan; Vol. 59 (1), pp. 20-29. Date of Electronic Publication: 2016 Nov 21.
DOI: 10.1111/jcpp.12652
Abstrakt: Background: Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children.
Methods: This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3-10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC).
Trial Registration Number: UMIN-CTR Study Design: trial number: UMIN000020281.
Results: Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.
Conclusions: This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.
(© 2016 Association for Child and Adolescent Mental Health.)
Databáze: MEDLINE
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