Hydrogel-thickened nanoemulsions based on essential oils for topical delivery of psoralen: Permeation and stability studies.

Autor: Barradas TN; Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro (IMA/UFRJ), Centro de Tecnologia, Bl. J, Avenida Horácio Macedo, 2030, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil. Electronic address: thaisbarradas@ima.ufrj.br., Senna JP; Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro (IMA/UFRJ), Centro de Tecnologia, Bl. J, Avenida Horácio Macedo, 2030, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil., Cardoso SA; Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro (IMA/UFRJ), Centro de Tecnologia, Bl. J, Avenida Horácio Macedo, 2030, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil., Nicoli S; Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43100 Parma, Italy., Padula C; Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43100 Parma, Italy., Santi P; Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43100 Parma, Italy., Rossi F; Instituto IMEM-CNR, Parco Area delle Scienze 37/a, 43100 Parma, Italy., de Holanda E Silva KG; Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho, 373, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil., Mansur CRE; Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro (IMA/UFRJ), Centro de Tecnologia, Bl. J, Avenida Horácio Macedo, 2030, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2017 Jul; Vol. 116, pp. 38-50. Date of Electronic Publication: 2016 Nov 17.
DOI: 10.1016/j.ejpb.2016.11.018
Abstrakt: Nanoemulsions (NE) have attracted much attention due to their as dermal delivery systems for lipophilic drugs such as psoralens. However, NE feature low viscosity which might be unsuitable for topical application. In this work, we produced hydrogel-thickened nanoemulsions (HTN) using chitosan as thickening polymer to overcome the low viscosity attributed to NE. The aim of this study is to develop and characterize oil-in-water (o/w) HTN based on sweet fennel and clove essential oil to transdermal delivery of 8-methoxsalen (8-MOP). NE components (oil, surfactant) were selected on the basis of solubility and droplet size and processed in a high-pressure homogenizer (HPH). Drug loaded NE and HTN were characterized for particle size, stability under storage and centrifugation, rheological behavior, transdermal permeation and skin accumulation. Transdermal permeation of 8-MOP from HTN was determined by using Franz diffusion cell. Transdermal permeation from HTN using clove essential oil showed strong dependency chitosan molecular weight. On the other hand, HTN using sweet fennel oil showed an unexpected pH-dependent behavior not fully understood at the moment. These results need further investigation, nevertheless HTN revealed to be interesting and complex dermal delivery systems for poorly soluble drugs.
(Copyright © 2016. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: