The influence of cortical bone perforation on guided bone regeneration in humans.

Autor: Danesh-Sani SA; Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, USA. Electronic address: sds521@nyu.edu., Tarnow D; Department of Periodontology, Columbia University College of Dental Medicine, New York, USA., Yip JK; Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, USA., Mojaver R; Private Practice, Tehran, Iran.
Jazyk: angličtina
Zdroj: International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2017 Feb; Vol. 46 (2), pp. 261-266. Date of Electronic Publication: 2016 Nov 16.
DOI: 10.1016/j.ijom.2016.10.017
Abstrakt: The purpose of this study was to evaluate the effect of cortical bone perforation on angiogenesis and osteogenesis of the augmented ridge in guided bone regeneration. Eighteen patients who had osseous defects in the mandible were selected. In the test group (n=9), alveolar cortical bone in the area of regeneration was perforated. No decortication was performed in the control group (n=9). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, trephine cores were harvested for histological and histomorphometric analysis of the grafted areas. Histomorphometry demonstrated that the amount of newly formed bone in the test group (27.8%) was greater than that in the control group (25.3%), but the difference was not statistically significant (P=0.13). However, the mean number of microvessels in the test group was significantly higher than that in the control group (P=0.01). This study found that cortical bone perforation favourably affects the amount of new bone formation in the grafted sites after 7 months of healing. Cortical bone perforation significantly increase number of new vessels (angiogenesis) of the regenerated bone. Further randomized clinical trials are required to confirm these results.
(Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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