Synthesis of Polydopamine-Like Nanocapsules via Removal of a Sacrificial Mesoporous Silica Template with Water.

Autor: Nador F; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Edificio ICN2, Campus UAB, Bellaterra, 08193, Barcelona, Spain., Guisasola E; Depto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Instituto de Investigación Sanitaria Hospital 12 de Octubre, i+12 Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n., 28040, Madrid, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain., Baeza A; Depto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Instituto de Investigación Sanitaria Hospital 12 de Octubre, i+12 Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n., 28040, Madrid, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain., Villaecija MA; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Edificio ICN2, Campus UAB, Bellaterra, 08193, Barcelona, Spain., Vallet-Regí M; Depto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Instituto de Investigación Sanitaria Hospital 12 de Octubre, i+12 Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n., 28040, Madrid, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain., Ruiz-Molina D; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Edificio ICN2, Campus UAB, Bellaterra, 08193, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Feb 24; Vol. 23 (12), pp. 2753-2758. Date of Electronic Publication: 2016 Dec 20.
DOI: 10.1002/chem.201604631
Abstrakt: Hollow polymeric polydopamine (PDA) micro-/nanocapsules have been obtained through a very simple, mild, and straightforward method that involves coating of silica mesoporous nanoparticles through an ammonia-triggered polymerization of PDA and the posterior removal of the sacrificial template simply by dispersion in water, without the need of any harsh chemical reagent, either in the presence or absence of active principles, from doxorubicin to iron oxide nanoparticles. To demonstrate the potential of the nanocapsules obtained with this new approach, they have been successfully used as nanocarriers for drug delivery.
(© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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