Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity.
| Autor: | Vuolo F; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany., Mentink RA; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany., Hajheidari M; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany., Bailey CD; Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003, USA., Filatov DA; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom., Tsiantis M; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Genes & development [Genes Dev] 2016 Nov 01; Vol. 30 (21), pp. 2370-2375. Date of Electronic Publication: 2016 Nov 16. |
| DOI: | 10.1101/gad.290684.116 |
| Abstrakt: | Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base. A single amino acid substitution evolved together with this regulatory change, which reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expression. We detected hallmarks of positive selection in these evolved regulatory and coding sequence variants and showed that modulating RCO activity can improve plant physiological performance. Therefore, interplay between enhancer and coding sequence evolution created a potentially adaptive path for morphological evolution. (© 2016 Vuolo et al.; Published by Cold Spring Harbor Laboratory Press.) |
| Databáze: | MEDLINE |
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