Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

Autor: Lotta LA; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Gulati P; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Day FR; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Payne F; Wellcome Trust Sanger Institute, Hinxton, UK., Ongen H; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., van de Bunt M; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Gaulton KJ; Department of Pediatrics, University of California at San Diego, La Jolla, California, USA., Eicher JD; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Sharp SJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., De Lucia Rolfe E; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Stewart ID; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Wheeler E; Wellcome Trust Sanger Institute, Hinxton, UK., Willems SM; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Adams C; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Yaghootkar H; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Johnson AD; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Semple RK; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Frayling T; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Perry JR; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Dermitzakis E; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Barroso I; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Savage DB; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., O'Rahilly S; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Jazyk: angličtina
Zdroj: Nature genetics [Nat Genet] 2017 Jan; Vol. 49 (1), pp. 17-26. Date of Electronic Publication: 2016 Nov 14.
DOI: 10.1038/ng.3714
Abstrakt: Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link with higher cardiometabolic risk is underpinned by an association with lower adipose mass in peripheral compartments. Using these 53 loci, we show a polygenic contribution to familial partial lipodystrophy type 1, a severe form of insulin resistance, and highlight shared molecular mechanisms in common/mild and rare/severe insulin resistance. Population-level genetic analyses combined with experiments in cellular models implicate CCDC92, DNAH10 and L3MBTL3 as previously unrecognized molecules influencing adipocyte differentiation. Our findings support the notion that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.
Databáze: MEDLINE