Papillomavirus assembly: An overview and perspectives.

Autor: Cerqueira C; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Schiller JT; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: schillej@mail.nih.gov.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2017 Mar 02; Vol. 231, pp. 103-107. Date of Electronic Publication: 2016 Nov 10.
DOI: 10.1016/j.virusres.2016.11.010
Abstrakt: Papillomavirus life cycle is tightly coupled to epithelial cell differentiation, which has hindered the investigation of many aspects of papillomavirus biology, including virion assembly. The development of in vitro production methods of papillomavirus pseudoviruses, and the production of "native" virus in raft cultures have facilitated the study of some aspects of the assembly process. In this paper we review the current knowledge of papillomavirus assembly, directions for future research, and the implications of these studies on new therapeutic interventions.
(Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: