MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.

Autor: Weck ML; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States., Grega-Larson NE; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States., Tyska MJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States. Electronic address: matthew.tyska@vanderbilt.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2017 Feb; Vol. 44, pp. 68-78. Date of Electronic Publication: 2016 Nov 09.
DOI: 10.1016/j.ceb.2016.10.002
Abstrakt: Unconventional myosins are actin-based molecular motors that serve a multitude of roles within the cell. One group of myosin motors, the MyTH4-FERM myosins, play an integral part in building and maintaining finger-like protrusions, which allow cells to interact with their external environment. Suggested to act primarily as transporters, these motor proteins enrich adhesion molecules, actin-regulatory proteins and other factors at the tips of filopodia, microvilli, and stereocilia. Below we review data from biophysical, biochemical, and cell biological studies, which implicate these myosins as central players in the assembly, maintenance and function of actin-based protrusions.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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