Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents.

Autor:	Herneisey M; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Williams J; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Mirtic J; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Liu L; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Potdar S; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Bagia C; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Cavanaugh JE; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA., Janjic JM; Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA 15219, USA.
Jazyk:	angličtina
Zdroj:	Therapeutic delivery [Ther Deliv] 2016 Dec; Vol. 7 (12), pp. 795-808. Date of Electronic Publication: 2016 Nov 11.
DOI:	10.4155/tde-2016-0050
Abstrakt:	Aim: Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release. Conclusion: PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases. [Formula: see text]. Competing Interests: Financial & competing interests disclosure J Janjic, L Liu and M Herneisey are supported by National Institute on Drug Abuse, grant number: R21DA039621-02 and National Institute of Biomedical Imaging and Bioengineering, grant number: R21EB02310-01. C Bagia was supported by Duquesne University Research Funds. J Cavanaugh was supported by Faculty Development Funds, Duquesne University. J Mirtic was supported by the Undergraduate Research Program at Duquesne University funded by the National Science Foundation, Major Research Instrumentation, Grant Number: CHE-1126465 and by the NIH, grant number: 1 R25 DA032519-01. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu