Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years.

Autor:	Rossi F; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Divisão Laboratório Central, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil. Electronic address: flaviarossi61@gmail.com., Girardello R; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Divisão Laboratório Central, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil., Cury AP; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Divisão Laboratório Central, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil., Di Gioia TS; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Divisão Laboratório Central, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil., Almeida JN Jr; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Divisão Laboratório Central, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil., Duarte AJ; Universidade de São Paulo, Faculdade de Medicina, Medicina Laboratorial - LIM-03, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2017 Jan - Feb; Vol. 21 (1), pp. 98-101. Date of Electronic Publication: 2016 Nov 08.
DOI:	10.1016/j.bjid.2016.09.011
Abstrakt:	Colistin resistance involving Gram-negative bacilli infections is a challenge for health institutions around of the world. Carbapenem-resistance among these isolates makes colistin the last therapeutic option for this treatment. Colistin resistance among Enterobacteriaceae, Acinetobacter spp., and Pseudomonas spp. was evaluated between 2010 and 2014 years, at Hospital das Clínicas, São Paulo, Brazil. Over five years 1346 (4.0%) colistin resistant Gram-negative bacilli were evaluated. Enterobacteriaceae was the most frequent (86.1%) pathogen isolated, followed by Acinetobacter spp. (7.6%), and Pseudomonas spp. (6.3%). By temporal analysis there was a trend for an increase of colistin resistance among Enterobacteriaceae, but not among non-fermentative isolates. Among 1346 colistin resistant isolates, carbapenem susceptibility was observed in 21.5%. Colistin resistance in our hospital has been alarmingly increased among Klebsiella pneumoniae isolates in both KPC positive and negative, thus becoming a therapeutic problem. (Copyright © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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