[Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru].

Autor: Davalos L; Universidad Peruana Cayetano Heredia. Lima, Perú., Terrazas Y; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Quintana A; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Egoavil M; Universidad Peruana Cayetano Heredia. Lima, Perú., Sedano K; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Castillo ME; Universidad Peruana Cayetano Heredia. Lima, Perú.; Instituto Nacional de Salud del Niño. Lima, Perú., Reyes I; Hospital de Emergencias Pediátricas. Lima, Perú., Chaparro E; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Silva W; Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú., Campos F; Hospital Nacional Docente Madre-Niño San Bartolomé. Lima, Perú., Saenz A; Hospital Daniel A. Carrión. Lima, Perú., Hernandez R; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Águila OD; Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú., Pinto DG; Universidad Peruana Cayetano Heredia. Lima, Perú.; Hospital Nacional Cayetano Heredia. Lima, Perú., Ochoa TJ; Universidad Peruana Cayetano Heredia. Lima, Perú.; University of Texas, School of Public Health. Houston, Texas, United States of America.
Jazyk: Spanish; Castilian
Zdroj: Revista peruana de medicina experimental y salud publica [Rev Peru Med Exp Salud Publica] 2016 Jul-Sep; Vol. 33 (3), pp. 425-431.
DOI: 10.17843/rpmesp.2016.333.2349
Abstrakt: Objectives.: To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru.
Materials and Methods.: A case series of pneumococcal meningitis in children less than 16 years of age from two prospective, multicenter, passive surveillance studies of invasive pneumococcal diseases held in Lima-Peru from 2006 to 2008 and 2009 to 2011.
Results.: We report 44 pneumococcal meningitis episodes; 68.2% of them were in children less than 2 years old. The overall case fatality rate was 32.6%; 92.9% of fatal cases were in children less than 2 years of age (p<0.05). Malnutrition was associated with fatal cases (p<0.05). 64.3% of fatal cases died within the first two days. 41.9% of pneumococcal isolates were resistant to penicillin, 23.3% were intermediate resistant to ceftriaxone (none were highly resistant) and 9.3% were resistant to chloramphenicol. The most common serotypes were 6B, 14, 19F and 23F, which accounted for 68.3% of all strains; 84.1% of strains were PCV13 serotypes.
Conclusions.: Pneumococcal meningitis continues to be a lethal disease, especially in children less than 2 years of age. Since almost two third of lethal cases lead to death within the first 48 hours, prompt diagnosis and management is critical, as well as assurance of immunization with pneumococcal vaccine.
Databáze: MEDLINE
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