Diagnostic Challenges in a Case of IgG4-RD Affecting the Temporal Bone.

Autor:	Vuncannon JR; 1 Wake Forest School of Medicine, Bowman Gray Center for Medical Education, Winston Salem, North Carolina, USA., Panella NJ; 2 Emory School of Medicine, Department of Otolaryngology-Head & Neck Surgery, Atlanta, Georgia, USA., Magliocca KR; 3 Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, USA., Mattox DE; 2 Emory School of Medicine, Department of Otolaryngology-Head & Neck Surgery, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2017 Mar; Vol. 126 (3), pp. 241-244. Date of Electronic Publication: 2016 Nov 13.
DOI:	10.1177/0003489416678009
Abstrakt:	Introduction: Immunoglobulin G4-related disease (IgG4-RD) is a recently described fibroinflammatory condition with a characteristic histology. While IgG4-RD can affect a great variety of anatomical sites, it has been seldom described in the temporal bone. Methods: Herein, a case IgG4-RD occurring in the temporal bone of a 35-year-old woman is reported. Discussion: This case of IgG4-RD of the temporal bone proved a uniquely challenging diagnosis due to slightly atypical histology falling outside of "highly suggestive" criteria. Conclusions: We suggest that IgG4-RD remains a challenging diagnosis to reach despite increased awareness of the condition. We further suggest that clinicopathologic correlation remain the cornerstone of diagnosis as the spectrum of presentations of this newly described disease may be wider than previously anticipated.
Databáze:	MEDLINE
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