| Autor: |
Bechtold C; Acquandas GmbH, Kaiserstrasse 2, 24143, Kiel, Germany. bechtold@acquandas.com., de Miranda RL; Acquandas GmbH, Kaiserstrasse 2, 24143, Kiel, Germany., Chluba C; Acquandas GmbH, Kaiserstrasse 2, 24143, Kiel, Germany.; Institute for Materials Science, Faculty of Engineering, University of Kiel, Kaiserstrasse 2, 24143, Kiel, Germany., Quandt E; Institute for Materials Science, Faculty of Engineering, University of Kiel, Kaiserstrasse 2, 24143, Kiel, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomedical microdevices [Biomed Microdevices] 2016 Dec; Vol. 18 (6), pp. 106. |
| DOI: |
10.1007/s10544-016-0131-6 |
| Abstrakt: |
Self-expandable medical devices provide mechanical functionality at a specific location of the human body and are viable for minimal invasive procedures. Besides radiopaque markers and drug-eluting coatings, next generation self-expandable devices can be equipped with additional functionality, such as conductive and flexible electrodes, which enables chronic recording of bioelectrical signals, stimulating or ablating tissue. This promises new therapeutic options in various medical fields, among them in particular neuromodulation (e.g. deep brain stimulation), BioMEMS, radio frequency ablation, mapping or denervation. However, the fabrication of such multi-functional devices is challenging. For this study we have realized a 35 μm thick, superelastic NiTi thin film stent structure with six isolated electrodes on the outer circumference, each electrode connected to a contact pad at the end of the stent structure, using magnetron sputtering, UV lithography and wet chemical etching. Mechanical and electrical properties of the device during typical loading conditions, i.e. crimping, simulated pulsatile and electrochemical testing, were characterized and reveal promising results. For the fabrication of future multifunctional, minimal invasive medical devices, such as electroceuticals or other intelligent implants, NiTi thin film technology is therefore a versatile alternative to conventional fabrication routes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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